In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Ibuprofen as a template molecule for drug design against Ebola virus.

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-...

Ebola Treatment and Prevention are not the only Battles: Understanding Ebola-related Fear and Stigma

بیماری ویروسی ابولا: یک تهدید جدی

Background: Ebola Virus Disease (EVD) has been known as a hemorrhagic fever, a severe and often fatal illness among humans.  Materials and Methods: This virus is transmitted through contact with the blood or body fluids of an infected person, infected objects such as needles, infected animals or bush meat. The history of mortality was more than 80 percent, but modern medical and public he...

A Short Overview of Ebola Outbreak

  Ebola virus disease (formerly known as Ebola haemorrhagic fever) is a severe, often fatal illness, with a death rate of up to 90%. The illness affects humans and nonhuman primates (monkeys, gorillas, and chimpanzees). Ebola first appeared in 1976 in two simultaneous outbreaks, one in a village near the Ebola River in the Democratic Republic of Congo, and the other in a remote area of Sudan. T...

Anemia during Hospitalization in the Patients with Ebola Virus Disease

Ebola virus disease is the important emerging disease in Africa. This infection is deadly and has the main clinical feature as an acute hemorrhagic fever. The main hematological alteration in this infection is the platelet change. However, the change in other hematological parameters should be mentioned.